Gangliosides

Gangliosides

What Are Gangliosides?1

Gangliosides (GG) are complex molecules that contain both lipids and carbohydrates. GG are found mostly in the brain and spinal cord. They are particularly concentrated at the synapses where neurons (brain cells) communicate with each other. Adequate supply of GG is essential for better neuron signaling.

Dietary GG are digested, absorbed and reassembles in body tissues with the help of other nutrients like protein and vitamins.1

Benefits of Gangliosides2

Vital component in the central nervous system

Supports cognitive function

Influences learning ability

GG are essential for the maturation and maintenance of the central nervous system.

GG contribute to the growth of the brain, formation of nerve cells and connections between them. They are involved in the transmission of neuronal signals, process of information storage in the brain, and are important for memory and learning.

GG may have a favourable effect on cognitive processes, especially in the early postnatal period when the child’s brain is still developing.

Sources of Gangliosides3

Gangliosides are typically found in animal-derived food such as meat, fish, egg yolk and dairy products. They can also be found in children’s milk formula. 

Signs and consequences of Ganglioside Deficiency 3

Nervous system inflammation

Neurodegeneration

GG deficiency takes place when the body is not able to produce or make GG from the available resources. This also occurs when nutrients essential for the synthesis of GG are in deficiency.4

The nervous system may suffer harm from GG deficiency-induced brain neurodegeneration, which includes disorders like Alzheimer’s, Dementia, Aphasia, and others.4

Did You Know?

10% of lipid found in the brain are Gangliosides.5

References:
Yu RK, Tsai YT, Ariga T, Yanagisawa M. 2011;60(10):537-44.
Gurnida DA et al. Early Hum Dev. 2012 Aug;88(8):595-601. 
Ohmi Y. J Neuroinflammation. 2014 Mar 28;11:61
Sandhoff K et al. J Neurosci. 2013;33(25):10195-10208.
Palmano K et al. Nutrients. 2015 May 22;7(5):3891-913

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