Gangliosides (GG)

GG are important components of neural cell membranes and are essential for brain development and the normal functioning of the nervous system.^1,2

GG play essential roles in transmitting signals between nerve cells, forming new nerve cells and the connections between them (synapses) and adjusting the strength of these connections.² These processes collectively contribute to the brain's capacity for adaptability (neuroplasticity), which is crucial for learning and memory.²

GG may have a favourable effect on cognitive processes, especially in the early postnatal period when the child’s brain is still developing.²

Sources of GG

GG are typically found in animal-derived food such as meat, fish, egg yolk and dairy products.³

Signs and consequences of GG deficiency

Consequences of low gangliosides intake or disruptions in ganglioside metabolism include impaired brain development, neurological disorders, cognitive behavioural effects and increased suseptability to infections.³

GG deficiencies are relatively rare in healthy individuals with a balanced diet. They are typically associated with rare genetic disorders or specific medical conditions rather than a lack of dietary intake. GG are primarily synthesised within the body, and dietary sources are not the primary source of gangliosides for most people.³

Did you know?

10% of the lipids found in the brain are GG.²